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Efficacy Of Monolaurin In Epidemic Diarrhea Of Piglet

Porcine epidemic diarrhea (PEDV) is mainly caused by porcine Epidemic diarrhea virus (PEDV) of the genus Coronaviridae, Nedoviridae, and is clinically characterized by acute enteritis, vomiting, watery diarrhea, dehydration, and high mortality of lactating piglets.

Viral diarrhea is easy to break out in pigs with poor insulation, low temperature, high humidity, low feed nutrition level and even feed mildew. Viral diarrhea has the characteristics of rapid infection, high morbidity and high mortality, so it will lead to low production performance of infected pigs. After 2010, there were many outbreaks of large-scale death of piglets caused by mutated porcine epidemic diarrhea virus strain in pig farms in China, which had a great impact on the pig industry.

Clinical symptoms of porcine epidemic diarrhea

1. Sow

Yellowish or grayish diarrhea with decreased feed intake and depression.

2. Piglets in the delivery room

Vomiting, watery diarrhea and other symptoms accompanied by depression, anorexia, weight loss and exhaustion. Piglets less than 1 week old often die of dehydration within 24-48 hours after diarrhea, with a case fatality rate of about 50-100%.

3. Weaned pigs, finishing pigs

The incidence is high, but the symptoms are mild, showing depression and diarrhea, lasting 4-7 days, and gradually returning to normal.

4. Nursery Pigs and birthing Piglets

From the first case of diarrhea, infection of other piglets of the same age in the unit occurred within 24-48 hours.

 

Monolaurin (GML) antiviral capabilities

Monolaurin is composed of a molecule of lauric acid and glycerol and is found naturally in breast milk and coconut oil. It can improve the intestinal health of cultured animals, play antibacterial, antiviral, antitoxin and anti-inflammatory functions.

 

Monolaurin is hydrophobic and lipophilic, and can bind to the hydrophobic region of the viral membrane, changing the structure and stability of the membrane, resulting in the breakdown of the viral membrane and loss of integrity. This prevents the virus from invading host cells and releasing its genetic material.

So, does GML have a therapeutic effect on piglet PEDV? Sichuan Agricultural University Veterinary College and other team scientists have done corresponding research:

1.Viral load in intestinal tissue and feces of piglets fed GML decreased (A1, A2, and A3 were treated with different doses of GML, B was the control, and C was the viral group, the same below).

Viral load in intestinal tissue and feces of piglets fed GML decreased

2.GML reduced IL-1β, IL-6, and IL-10 levels in a dose-dependent manner.

GML reduced IL-1β, IL-6, and IL-10 levels in a dose-dependent manner.

3.GML can effectively slow the weight loss of piglets and subsequently restore their growth performance

GML can effectively slow the weight loss of piglets and subsequently restore their growth performance

 

This study demonstrated that GML has a potential anti-PEDV effect in vivo. GML can not only restore the growth performance of piglets, but also reduce the degree of intestinal pathological damage, and reduce the viral load of intestinal tissue and mesenteric lymph nodes. More importantly, lauryl ester showed good anti-inflammatory properties, it can reduce intestinal inflammation after virus infection, reduce the degree of disease. This finding provides a new idea for the treatment of epidemic diarrhea of piglets.

Expansion: How should pig farms control the further spread of the disease after the outbreak?

1. Worthless piglets should be eliminated

2. Valuable piglets are immediately transferred and raised in isolation at fixed points

3. Effectively seal the field, wash the empty fence, disinfect the pig, clean and dry, heat preservation and ventilation, and access control

4.The removal of feces is the key to the prevention and control of diarrhea

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Calid Biotech (Wuhan) Co., Ltd. is a specialized company that focuses on the R&D, manufacturing, promoting, and application of new technologies and products for animal lipid nutrition, providing solutions for the feed-grade fatty acid balancing to customers in the livestock and fishery field.

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